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[21] [22] Conversely, symptoms of adrenal insufficiency such as severe fatigue, weight loss, hypotension, or hypoglycemia require urgent assessment, typically starting with morning serum cortisol and possibly ACTH stimulation testing

Tirzepatide targets GLP-1 and GIP receptors to reduce appetite and improve glycemic control, while sermorelin stimulates endogenous growth hormone secretion to enhance lean muscle preservation and metabolic rate during weight loss

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95% CI, 0.590.98), as well as a significantly lower incidence rate of HHF (13.0 versus 20.8 per 1,000 person-years

doi: 10.1016/j.bbadis.2024.167645 52 LiGLiuCYangLFengLZhangSAnJet al